Dysregulation of Kv3.4 Channels in Dorsal Root Ganglia Following Spinal Cord Injury

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Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury.

Spinal cord injury (SCI) patients develop chronic pain involving poorly understood central and peripheral mechanisms. Because dysregulation of the voltage-gated Kv3.4 channel has been implicated in the hyperexcitable state of dorsal root ganglion (DRG) neurons following direct injury of sensory nerves, we asked whether such a dysregulation also plays a role in SCI. Kv3.4 channels are expressed ...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2015

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.1594-14.2015